I do not think so. I think they have to be the gameboy advance to work on the ds or ds lite. Not totally sure though. This game is the original gameboy. Before the advance came out. A quick Q&A at toysrus.com might help answer you for sure.
IT DOES NOT WORK WITH DS SYSTEMS; JEEZUS!!!!!! If you did not know you should have done your research first, you put everyone's bid at risk! How stupid are people getting these days?! *This message is for skeeterbaby86*
*cardia0* No Need To Be Rude! I Don't See How Me Asking Puts Everyone's Bids At Risk. Sounds Like You're The Stupid One, Not Me. At Least I Asked Before I Bid, You Rude Person!